![]() Every two to four hours, nurses collected blood and urine samples, took FEV1 metrics, and also measured airway resistance, which indicates if swelling or mucus buildup are making it harder to move air through the lungs. Participants were hooked up to thermometers that monitored their core temperatures almost continuously. “The constant routine protocol is based on the concept that you remove any 24-hour rhythmicity and any factors, environmental or behavioral, that may induce changes in physiology,” says Scheer. ![]() Or, Shea adds, “maybe it’s the internal body clock.” Or it may be caused by body position or mites or allergens in the bedding. "Most people sleep at night, so maybe it’s the sleep that causes your asthma to get worse at night," he says. Yet no one is sure why asthma gets worse at night, says Steven Shea, director of the Oregon Institute of Occupational Health Sciences at Oregon Health and Science University. ![]() A famous mortality survey of London hospitals in the 1970s showed that early morning and nighttime attacks were more likely to be fatal. Hundreds of years later, scientists were finding evidence that backed him up: A study from 2005 showed that nearly 75 percent of people with asthma experience worse attacks at night. But Floyer’s piece also noted another important symptom: His own asthma was almost always more severe at night, sometimes waking him up at 1 or 2 in the morning. In an asthma attack, the air passageways in a person’s lungs start to close, making it hard for them to breathe and causing tightness in the chest, coughing, and wheezing. He warned that those who were sad or angry were more likely to experience attacks, as sadness would stop the “Motion of Humors.” He also recommended a few cures including regular, gentle vomiting. In 1698, British doctor John Floyer wrote a treatise on asthma, the first major work focused on the disease.
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